First step in bioengineering human uterus to treat endometrial diseases

Bioengineering human uterus to treat endometrial diseases

First step in bioengineering human uterus to treat endometrial diseases. Researchers at Northwestern Medicine Just took the first step in bioengineering the human uterus to treat endometriosis, uterine-factor infertility and endometrial cancer.

Steps in bioengineering human uterus to treat endometrial diseases

Endometriosis occurs when the endometrial cells in a woman’s uterus do not respond to an adequate amount of an implantation hormone called progesterone.The abnormal cells, called defective endometrial stromal fibroblasts, travel through the fallopian tubes. As such, they then proceed onto the lower abdominal tissues and the ovaries. Extra-uterine growth of endometrium-like tissue results in severe pelvic pain. In addition, they lead to infertility, development of adhesions and increases the risk for ovarian cancer.

The study is the first to demonstrate that induced human pluripotent stem (iPS) cells, with reprogramming, can become healthy uterine cells for potential placement in the uterus. Made from a person’s own readily available cells, iPS cells can potentially be manipulated to fix defects within other, disease-causing cells. The healthy cells are then optimal for an auto-transplant that won’t be rejected by the person’s immune system.

The study’s date of publication was Nov. 1 in the journal Stem Cell Reports.

“This is huge. We’ve the door open to treating endometriosis,” says senior author Dr. Serdar Bulun, who has been researching treatments for endometriosis for the past 25 years. “These women with endometriosis start suffering from the disease at a very early age. So, we end up seeing young high school girls getting opioids adiction, which totally destroys their academic potential and social lives.”

Bulun is the chair of the department of obstetrics and gynecology at Northwestern University Feinberg School of Medicine. Further he is a Northwestern Medicine physician.

First step in bioengineering human uterus to treat endometrial diseases

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